RHCC
ProtR-C is a drug delivery vehicle developed from a platform based on the RHCC
fragment of the tetrabrachion protein complex of Staphylothermus marinus (S.marinus).
S.marinus is an archaebacterium isolated from the black smokers of the East Pacific
Rise. The RHCC protein fragment is small; about 7.5 x 2.5 nm2, rod shaped, and has interior hydrophobic cavities. A range of metal complexes bind stably to the interior
cavities, and this property is taken advantage of when developing RHCC for drug
delivery.
The RHCC is
• Extremely stable
• Easy to produce in large quantities
• Ideally sized for a carrier
The RHCC as a drug carrier
• Increases efficacy
• Reduces side-effects
• Expands indications
The product developed is:
ProtR-C: The RHCC loaded with cisplatin for drug delivery to tumor
by EPR or targeting effect.
Partners in development of the RHCC technology platform are Karolinska Institute,
Uppsala University, Linköping University, and Heidelberg University.
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